• Drug Class:
    Selective Estrogen Receptor Modulator
  • Units:
    20 mg/tab
  • Active Substance:

    Tamoxifen Citrate


What is Tamoxiplex – Use and Dosages, Side Effects

Tamoxiplex is Tamoxifen Citrate, which blocks estrogen, a female hormone. Estrogen helps pushing up certain kinds of cancers among women. Breast cancers among men and women are common and Tamoxifen Citrate or Tamoxiplex can be a good supportive measure.

Tamoxifen is also marketed as Nolvadex, a prominent anti-estrogen component. It is used post mastectomy, segmental mastectomy and auxiliary dissection alongside breast irradiation among women and men with threatening issues of cancerous upgrades. The auxiliary node-negative breast cancer patients need Tamoxiplex to garner long-term benefits with prevention of spreading cancer.


Early breast cancer issues had been perfectly countered by using Tamoxiplex (Nolvadex) as placebo by using the dosage as 20 to 40mg per day for 1.5 years. Estrogen receptors can perfectly deal with suppressing the level of estrogen in the body. As placebo treatment, 10 years of Nolvadex had been effective to treat cancer patients.

The similar time span is still acceptable for a proper treatment through Tamoxiplex. After 6.75 years on average, it has been found that 76% of Tamoxiplex or Tamoxifen’s effectiveness can prevent cancer. It can also be used to prevent gynecomastia among the men.

Tamoxiflex can be effective for ovulation induction for the patients with anovulatory disorders and related issues. The dosages may be depended upon the prescription of the doctors. It has already been stated that the therapeutic dosage would be maintained for over 7 to 10 years. A placebo for 5 years has been effective for the women of 35 years of age. Over the time, it would be ideal for the people to meet the experts to learn about the dosages.

Pharmacokinetic Data

The component has about 100% bioavailability and should be taken by mouth as an oral dosage. The protein binding is as equal as >99% (albumin). The component is hepatic and effective with metabolites as Afimoxifene, Endoxifen and Norendoxifen. The elimination half-life for the component is of about 5 to 7 days. It is excreted through feces (65%) and urine (9%).


Tamoxiplex is linked to the predominantly antiestrogenic effects in the breasts. Tamoxiplex needs a protein PAX2 for a complete anticancer effect. A prominent workability with the growth factors may act as a beneficial as well as risky for Tamoxiplex. When the contractions properly suppresses ERBB2 protein and gets the AIB-1 expression higher than PAX2, it becomes a prominent breast cancer medication. It also decrease the Insulin-like Growth Factor-1 or IGF-1 among women to prevent estrogenic reactions to remain active in the process of suppressing cancerous growth in the body.

Side effects

Being affected with the overdoses is not uncommon for Tamoxiplex. Erythema is a common effect caused by the overdoses or even the usual doses of the compound Tamoxiplex. Thrombotic events after Tamoxiplex may be fatal. Patients with gynecomastia may consider having Anastrazole 1mg alongside Tamoxiplex 20mg may feel it safer to consume the components.

The prominent side effects are visible with the bones, where they feel the lack of bone-losing effects for estrogen reduction. This prevents osteoclasts among the patients using Tamoxiplex. However, on the other hand, this component may be an agonist linked to endometrial cancer among some women. Deep vein thrombosis, cardiovascular issues may be a common outcome of persistent use of Tamoxiplex. It may also cause weight gaining among the users.

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